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The defending Major League Baseball champion San Francisco Giants aims for their 5th straight wins when they play host to the visiting Arizona Diamondbacks on Wednesday evening.Sporting a 19-16 record, the home-team San Francisco Giants is picked as favorite to win over the Arizona Diamondbacks due to their superior record.

The San Francisco Giants is also picked to win over the Arizona Diamondbacks since they already beaten the latter 1-0 in their initial encounter Tuesday.Having won four straight games, the San Francisco Giants are fired up to continue with its winning run and beat the Arizona Diamondbacks for the second straight game.

In the head-to-head match-up between the two teams, the San Francisco Giants had a decisive advantage as they have won 16 of their 20 meetings against the Arizona Diamondbacks, including eight of 10 and five in a row at home.To defeat the Diamondbacks, the Giants need to play stellar in the entire game against their visitor.

Giants starting pitcher Jonathan Sanchez (2-2, 3.55 ERA) also need to play his A-game to bring his team to victory against the Diamondbacks.The odds of winning is on the side of the Giants in this game all they need to do is to play smart come game-time.

The Diamondbacks for its part face a huge challenge in beating the Giants in this game.Losing seven of their eight road games, the Diamondbacks are in dire need of a win against the Giants.

To bring down and upset the Giants, Diamondbacks starting pitcher Armando Galarraga need to be at his best in this game.The Diamondbacks might be the huge underdog in this game but they can still win if they can come up with a good game-plan and execute it well on game day.